加拿大pc

加拿大pc医学部朱卫国教授团队揭示组蛋白修饰参与DNA复制的新机制

来源: 发布时间: 2020-06-10 11:11 点击数: Views

加拿大pcdnafuzhishiyigeshifenjingxidefenzidiaokongguocheng, zaidnafuzhiguochengzhongtineitiwaidaliangdecijiyinsuruuv、ransezhigaojijiegoudezulandenghuichanshengdnafuzhiyali(replication stress),congershidefuzhichatingzhi(fork stall)shenzhikuata(fork collapse)zaochengdnasunshang(dna damage),jinerdaozhijiyinzubuwending,yincidnafuzhiyingjidexiangyinghexiufuduiyubaozhengdnafuzhiwanchengdezhunquexingheransezhiwendingxingyijizhengchangdexibaomingyunjuyouzhongyaoyiyi。

2021nian6yue2ri,jianadapczhuweiguojiaoshoutuanduizai《meiguokexueyuanyuanbao》(pnas)zaixianfabiaotiweisetd2-mediated h3k14 trimethylation promotes atr activation and stalled replication fork restart in response to dna replication stressdezhangwenwenzhang,jieshilezudanbaijiajihuaxiushicanyudiaokongatrxinhaotonglujihuo,bingcujintingzhidednafuzhichazhongqidezhongyaogongneng。 gaixiangyanjiujiandinglexindezudanbaijiajihuaxiushiweidianh3k14me3dejiajihuamei,faxianzudanbaixiushinenggouzhijieyingxiangrpafuhewuzairansezhishangdezhaomu,congerjiangzudanbaixiushiyuatrxinhaotongludejihuolianxiqilai,shuomingzudanbaixiushicanyudiaokonglednafuzhiyalidezuikaishidexiangyingguocheng。jianadapczhuweiguojiaoshouheliuxiangyuyanjiuyuanweibenwendetongxunzuozhe,jianadapcboshihouzhuqianweibenwendediyizuozhe。

dnafuzhiyalitiaojianxiasetd2jiedaodeh3k14me3diaokongatrjihuodexinhaotonglu

yuanwenlianjie:

加拿大pc(yixuebu  gonggao)

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